How HS-CRP Testing Detects Heart Disease Early

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Did you know? In the UK, 100,000 hospital admissions each year are due to heart attacks—that's 290 daily or one every five minutes. Monitoring your inflammation levels with an hs-CRP test is vital for cardiovascular health.

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Why Should You Take thehs-CRP Test?

Testing your high-sensitivity C-reactive protein (hs-CRP) levels is an essential step in understanding your cardiovascular and overall health. This advanced test detects low inflammation in the body that may not cause immediate symptoms but indicate serious underlying issues. Higher hs-CRP levels are related to higher risk of coronary artery disease (CAD), heart attacks and other inflammatory conditions. And here's why this test is important:

  • Elevated Cardiac Risk (10%-20% Chance in 10 Years):

    If your 10-year risk of a cardiac event is moderately high, testing can help identify inflammation associated with cardiovascular disease (CVD).

  • Prevent Secondary Heart Attacks:

    For people with a history of heart attack this test determines recurrence risk and helps healthcare providers develop treatment plans and preventative measures.

  • Diagnose Inflammatory Diseases:

    Identify chronic conditions such as rheumatoid arthritis or lupus where CRP levels are common. Knowing these marks allows accurate diagnosis and management of autoimmune and inflammatory diseases.

  • Normal LDL Cholesterol (<130 mg/L):

    Individuals with normal LDL-C levels with other risk factors for heart disease will benefit from hs-CRP testing to identify hidden inflammation.

  • Age-Related Risk Factors:

    Men over 50 and women over 60 without existing heart disease or diabetes can use hs-CRP testing to identify low-grade inflammation due to aging.

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Symptoms Indicating theNeed for hs-CRP Testing

While no general consensus exists on routine hs-CRP testing, it can be informative in regard to persons at increased risk for cardiovascular or inflammatory conditions.

  • Unexplained Chest Pain

    Chest discomfort or tightness suggesting early cardiovascular issues.

  • Shortness of Breath

    Shortness of breath with mild exertion possibly related to cardiac or systemic disease.

  • Swelling in the Extremities

    Edema (swelling) of legs, feet or hands, unexplained, possibly indicative of cardiovascular stress.

  • Family Heart Disease

    A risk factor that warrants preventive hs-CRP screening for inflammation detection.

  • Existing Conditions

    Chronic diseases like diabetes, kidney disease or autoimmune disorders increase systemic inflammation and cardiac complications.

  • Chronic Health Conditions

    Systemic inflammation from diabetes, kidney disease or autoimmune disorders like lupus or rheumatoid arthritis makes hs-CRP testing useful for monitoring.

  • Persistent Fatigue or Joint Pain

    Systemic inflammation may be revealed by chronic fatigue, joint pain or unexplained symptoms - hs-CRP testing is therefore an essential diagnostic step.

  • Frequent Infections

    Recurrent illnesses may signal an overactive immune response or underlying inflammation affecting heart health.

How and What We Measure

CRP, or C-reactive protein, is a key marker in the blood that rises in response to inflammation or infection.  Elevated CRP may also occur after a heart attack, surgery or trauma. Persistent low-level inflammation detected by CRP testing is linked to atherosclerosis - narrowed blood vessels caused by cholesterol build-up - and increased risk of cardiovascular disease (CVD). The hs-CRP test measures even small elevations of CRP in blood with high specificity. Identifying persistent vascular inflammation predicts CVD risk and allows early intervention to limit health risks.

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    1. Standard CRP Test

    • Measures markedly high CRP levels (8–1000 mg/L).

    • Used to detect major inflammation-causing diseases such as infections or chronic inflammatory disorders.

    1. High-Sensitivity CRP (hs-CRP) Test:

    • Detects low levels of CRP (0.3–10 mg/L).

    • Evaluates individuals for cardiovascular disease risk and underlying low-grade inflammation.

What to Expect During Yourhs-CRP Test

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    You need no special preparation. Eat and drink normally before the test.


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Regular hs-CRP testing is essential for monitoring inflammation and assessing your cardiovascular risk, enabling early interventions to protect your heart and overall well-being.
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Understanding Your hs-CRP TestResults

Your hs-CRP test results can tell you about your body's inflammation and assess your cardiovascular risk. Here’s how they're interpreted:
HS-CRP Level (mg/L)What It Means for Your Health
HS-CRP Level (mg/L)
What It Means for Your Health
Less than 1 mg/L
Low Risk:Indicates low levels of inflammation and a reduced risk of cardiovascular disease. Maintain a healthy lifestyle. Retest annually or as advised.
1 to 3 mg/L
Moderate Risk:Indicates moderate levels of inflammation, which may slightly increase cardiovascular risk. Consider lifestyle changes and monitor health. Retest in 3-6 months.
More than 3 mg/L
High Risk:Indicates significant inflammation, associated with a higher risk of cardiovascular disease. Consult a healthcare provider for further evaluation and management. Retest as recommended.
Next Steps:Based on hs-CRP test results, your healthcare provider may recommend lifestyle changes like a heart-healthy diet and exercise, or perhaps medications to reduce inflammation, or additional diagnostic tests to identify and treat underlying causes.

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